Basic Research:
2024
Perlegos, A.E., Durkin, J., Belfer, S.J., Rodriguez, A., Shcherbakova, O., Park, K., Luong, J., Bonini, N.M. and Kayser, M.S., 2024. TDP-43 impairs sleep in Drosophila through Ataxin-2–dependent metabolic disturbance. Science Advances, 10(2), p.eadj4457.
2023
Durkin J, Poe AR, Belfer SJ, Rodriguez A, Tang SH, Walker JA, Kayser MS. Neurofibromin 1 regulates early developmental sleep in Drosophila. Neurobiology of Sleep and Circadian Rhythms. 2023 Nov 1;15:100101.
Poe, A.R., Zhu, L., Szuperak, M., McClanahan, P.D., Anafi, R.C., Scholl, B., Thum, A.S., Cavanaugh, D.J. and Kayser, M.S., 2023. Developmental emergence of sleep rhythms enables long-term memory in Drosophila. Science Advances, 9(36), p.eadh2301.
2021
Coll-Tané M, Gong NN, Belfer SJ, van Renssen LV, Kurtz-Nelson EC, Szuperak M, Eidhof I, van Reijmersdal B, Terwindt I, Durkin J, Verheij MMM, Kim CN, Hudac CM, Nowakowski TJ, Bernier RA, Pillen S, Earl RK, Eichler EE, Kleefstra T, Kayser MS, Schenck A. The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects. Sci Adv. 2021 Jun 4;7(23):eabe2626. doi: 10.1126/sciadv.abe2626.
Li D, Wang Q, Gong NN, Kurolap A, Feldman HB, Boy N, Brugger M, Grand K, McWalter K, Guillen Sacoto MJ, Wakeling E, Hurst J, March ME, Bhoj EJ, Nowaczyk MJM, Gonzaga-Jauregui C, Mathew M, Dava-Wala A, Siemon A, Bartholomew D, Huang Y, Lee H, Martinez-Agosto JA, Schwaibold EMC, Brunet T, Choukair D, Pais LS, White SM, Christodoulou J, Brown D, Lindstrom K, Grebe T, Tiosano D, Kayser MS, Tan TY, Deardorff MA, Song Y, Hakonarson H. Pathogenic variants in SMARCA5, a chromatin remodeler, cause a range of syndromic neurodevelopmental features. Sci Adv. 2021 May 12;7(20):eabf2066. doi: 10.1126/sciadv.abf2066.
Gong NN, Dilley LC, Williams CE, Moscato EH, Szuperak M, Wang Q, Jensen M, Girirajan S, Tan TY, Deardorff MA, Li D, Song Y, Kayser MS. The chromatin remodeler ISWI acts during Drosophila development to regulate adult sleep. Sci Adv. 2021 Feb 17;7(8):eabe2597. doi: 10.1126/sciadv.abe2597.
2020
Chakravarti Dilley L, Szuperak M, Gong NN, Williams CE, Saldana RL, Garbe DS, Syed MH, Jain R, Kayser MS. Identification of a molecular basis for the juvenile sleep state. Elife. 2020 Mar 23;9:e52676. doi: 10.7554/eLife.52676.
Moscato EH, Dubowy C, Walker JA, Kayser MS. Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction. Cell Rep. 2020 Jul 7;32(1):107856. doi: 10.1016/j.celrep.2020.107856.
2019
Churgin MA, Szuperak M, Davis KC, Raizen DM, Fang-Yen C, Kayser MS. Quantitative Imaging of Sleep Behavior in Caenorhabditis elegans and larval Drosophila melanogaster. Nature Protocols. doi: 10.1038/s41596-019-0146-6. (2019).
Brown EB, Slocumb ME, Szuperak M, Kerbs A, Gibbs AG, Kayser MS, Keene AC. Starvation resistance is associated with developmentally specified changes in sleep, feeding and metabolic rate. J Exp Bio. 8;222(Pt 3). pii: jeb191049.(2019).
Belfer SJ, Bashaw AG, Perlis ML, Kayser MS. A Drosophila model of sleep restriction therapy for insomnia. Molecular Psychiatry. doi: 10.1038/s41380-019-0376-6.(2019).
2018
Dilley LC, Vigderman A, Williams CE, Kayser MS. Behavioral and Genetic Features of Sleep Ontogeny in Drosophila. Sleep. doi: 10.1093/sleep/zsy086. (2018)
Szuperak M, Churgin MA, Borja AJ, Raizen DM, Fang-Yen C, Kayser MS. A sleep state in Drosophila larvae required for neural stem cell proliferation. eLife. 7:e33220 (2018).
**covered by Science
2017
Machado DR, Afonso DJ, Kenny AR, Öztu Rk-Çolak A, Moscato EH, Mainwaring B, Kayser MS, Koh K. Identification of octopaminergic neurons that modulate sleep suppression by male sex drive. eLife. 6:e23130 (2017).
2014-2016
Garbe DS, Vigderman AS, Moscato E, Dove AE, Vecsey CG, Kayser MS, Sehgal A. Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons. J Biol Rhythms. (2016)
Kayser MS, Mainwaring B, Yue Z, Sehgal A. Sleep deprivation suppresses aggression in Drosophila. eLife (2015);4:e07643.
Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A. Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proc Natl Acad Sci U S A. 112(8):2569-74 (2015).
Kayser MS, Yue Z, Sehgal A. A critical period of sleep for development of courtship circuitry and behaviors. Science (Research Article). 344:269-74 (2014).
**covered by Current Biology, Nature Reviews Neuroscience
BFF (Before Fruit Fly)
Nolt MJ, Lin Y, Hruska M, Murphy J, Sheffler-Colins SI, Kayser MS, Passer J, Bennett MV, Zukin RS, Dalva MB. EphB Controls NMDA Receptor Function and Synaptic Targeting in a Subunit-Specific Manner. J Neurosci 31:5353-64 (2011).
Kayser MS*, Lee AC*, Hruska M, Dalva MB. Preferential Control of Basal Dendritic Protrusions by EphB2. PLoS One. 6(2):e17417 (2011) (*authors contributed equally).
McClelland AC, Sheffler-Collins SI, Kayser MS, Dalva MB. Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1. Proc Natl Acad Sci 106:20487-92 (2009).
Kayser MS, Nolt MJ, Dalva MB. EphB receptors couple dendritic filopodia motility to synapse formation. Neuron 59:56-69 (2008).
Kayser MS, McClelland AC, Hughes EG, Dalva MB. Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci 26:12152-64 (2006).
Huber KM, Kayser MS, Bear MF. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science 288:1254-1256 (2000).
Review Articles/Book Chapters (Basic):
Doldur-Balli F, Imamura T, Veatch OJ, Gong NN, Lim DC, Hart MP, Abel T, Kayser MS, Brodkin ES, Pack AI. Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms. Sleep Med Rev. 2022 Jan 25;62:101595. doi: 10.1016/j.smrv.2022.101595.
Poe AR, Mace KD, Kayser MS. Getting into rhythm: developmental emergence of circadian clocks and behaviors. FEBS J. 2021 Aug 10. doi: 10.1111/febs.16157.
Gong NN, Kayser MS. Sleep: The Balm of Hurt Minds. Curr Biol. 2020 Mar 23;30(6):R263-R265. doi: 10.1016/j.cub.2020.02.032.
Boland E, Goldschmied J, Kayser MS, Gehrman PR. Precision Medicine for Insomnia. Sleep Med Clin. 2019 Sep;14(3):291-299. doi: 10.1016/j.jsmc.2019.04.001.
Chakravarti L, Moscato EH, Kayser MS. Unraveling the Neurobiology of Sleep and Sleep Disorders Using Drosophila. Curr Top Dev Biol 121:253-285 (2017).
Kayser MS and Biron D. Sleep and Development in Genetically Tractable Model Organisms. Genetics. 2016 May;203(1):21-33.
Kayser MS, Zheng X. Exploring a role for sleep in neural developmental and psychiatric disease. Journal of Sleep Disorders & Therapy 2(1) (2013).
Kayser MS, Wyse GA. Synapses. Chapter 11 in Animal Physiology, 2nd Edition, eds. Hill RW, Wyse GA, Anderson M. Sinauer Associates, Inc. Publishers, Sunderland, MA. (2008).
Dalva MB, McClelland AC, Kayser MS. Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci 8:206-20 (2007).
Kayser MS, Dalva MB. Synaptogenesis. Chapter 20 in Textbook of Neural Repair and Rehabilitation, eds. ME Selzer, LG Cohen, FH Gage, S Clarke, PW Duncan. Cambridge University Press, Cambridge, U.K. (2006).
Clinical Research:
Gehrman P, Gunter P, Findley J, Frasso R, Weljie AM, Kuna ST, Kayser MS. Randomized Noninferiority Trial of Telehealth Delivery of Cognitive Behavioral Treatment of Insomnia Compared to In-Person Care. J Clin Psychiatry. 2021 Aug 24;82(5):20m13723.
Goldschmied JR, Sengupta A, Sharma A, Taylor L, Morales KH, Thase ME, Thase ME, Weljie A, Kayser MS. Treatment of Insomnia with Zaleplon in HIV+ Significantly Improves Sleep and Depression. Psychopharmacol Bull. 2021 Jun 1;51(3):50-64.
Kayser MS. Examining a role for N-methyl-d-aspartate receptor autoantibodies in psychiatric illness. Biol Psychiatry 15;77(6):506-7 (2015).
Kayser MS, Dalmau J. Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr. Res (2014), http:// dx.doi.org/10.1016/j.schres.2014.10.007
Kayser MS, Titulaer MJ, Gresa-Arribas N, Dalmau J. Frequency and characteristics of isolated psychiatric episodes anti-NMDA receptor encephalitis. JAMA Neurology 70:1133-9. (2013).
Kayser MS, Dalmau J. Anti-NMDA receptor encephalitis in psychiatry. Curr Psych Rev 7:189-93 (2011).
Kayser MS, Dalmau J. The emerging link between autoimmune disorders and neuropsychiatric disease. J Neuropsychiatry Clin Neurosci 23:90-7 (2011).
Kayser MS, Kohler CG, Dalmau J. Psychiatric manifestations of paraneoplastic disorders. Am J Psychiatry 167:1039-50 (2010).
